AION
Research paperEfficiency & Inference · Training & Scaling · Large Language Models1 source · Oct 8, 2026

Ambient Discrete Diffusion: Using the Wrong Data at the Right Time for Data Efficient Learning

We introduce RefineMix, a framework for training discrete diffusion models under severe data scarcity, a common constraint in scientific applications.

Key points

  • RefineMix uses out-of-distribution data at selected diffusion times to improve generalization without biasing the sampling distribution.
  • Although this strategy has been explored in continuous diffusion, discrete diffusion presents a distinct challenge: unlike Gaussian noise, masking preserves domain information in surviving tokens, limiting the use of related data at high noise levels.
  • Experimentally, across five domain-shift settings, RefineMix matches or outperforms in-domain finetuning and data mixing.
  • For protein sequence generation, finetuning with just 197 in-domain examples nearly doubles the fraction of generated proteins that are simultaneously novel, foldable, and in-family compared to standard finetuning.

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