ResearchResearch paperEfficiency & Inference1 source · Oct 6, 2026

MARCO: The Radioactive Watermark for Protein Generative Models

Protein Generative Models (PGMs) have revolutionized structural biology by enabling the design of complex 3D protein structures from sequence data.

Key points

  • However, this breakthrough introduces a dual-use challenge, exposing high-value PGMs to economic risks like unauthorized model extraction and biosecurity threats such as biohazard synthesis.
  • Comprehensive experiments demonstrate that MARCO achieves superior fidelity and robustness while successfully validating watermark transferability.

Sources (1)

  • [1]MARCO: The Radioactive Watermark for Protein Generative Models
    arXiv (AI, ML, NLP, CV, robotics, multi-agent) · Oct 6, 01:18 PM
    Protein Generative Models (PGMs) have revolutionized structural biology by enabling the design of complex 3D protein structures from sequence data.
    However, this breakthrough introduces a dual-use challenge, exposing high-value PGMs to economic risks like unauthorized model extraction and biosecurity threats such as biohazard synthesis.

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