ResearchResearch paperLarge Language Models · Applications · Reasoning & Planning1 source · Oct 6, 2026

MedZERO: Self-Evolving Agents for Open-Ended Medical Reasoning Through Controlled Knowledge Accumulation

We present MedZERO, a self-evolving framework for open-ended medical reasoning.

Key points

  • Large language models (LLMs) have shown promise in medical question answering and clinical reasoning, yet their improvement remains constrained by static parametric knowledge and costly expert supervision.
  • Self-evolving agents offer a promising alternative by enabling models to improve through iterative task generation and problem-solving.
  • MedZERO couples an Examiner that generates frontier medical question-option pairs with a Reasoner that solves them through evidence-grounded multi-turn reasoning with external knowledge tools.
  • We evaluate MedZERO on five public medical reasoning benchmarks using 4B- and 8B-scale base models under open-ended evaluation.

Sources (1)

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