Social Pain Disrupts Emotion-Action Brain-State Dynamics in Adolescents with Non-Suicidal Self-Injury
Non-suicidal self-injury (NSSI) is prevalent among adolescents with depression, but the rapid brain-state dynamics linking social distress to maladaptive behavior remain unclear.
Key points
- We combine an experimental pain paradigm, electroencephalography (EEG) microstate analysis, and interpretable deep sequence modeling to investigate NSSI-related neurodynamics in 106 adolescents with depression, including 67 with NSSI (DN+) and 39 without NSSI (DN-), during social pain, physical pain, and resting-state conditions.
- Model interpretation and conventional microstate analyses reveal weakened bidirectional transitions between MS3 and MS5 in DN+ adolescents during social pain.
- Time-resolved analyses show greater early-to-middle action-state recruitment and later emotion-state recruitment in DN+ adolescents.
- Together, these findings identify disrupted emotion-action coupling as a key neurodynamic mechanism underlying altered social pain processing in adolescents with NSSI, providing a mechanistically interpretable neural signature for objective identification of NSSI.
Sources (1)
- [1]Social Pain Disrupts Emotion-Action Brain-State Dynamics in Adolescents with Non-Suicidal Self-InjuryarXiv (AI, ML, NLP, CV, robotics, multi-agent) · Oct 8, 03:16 AM
Non-suicidal self-injury (NSSI) is prevalent among adolescents with depression, but the rapid brain-state dynamics linking social distress to maladaptive behavior remain unclear.
We combine an experimental pain paradigm, electroencephalography (EEG) microstate analysis, and interpretable deep sequence modeling to investigate NSSI-related neurodynamics in 106 adolescents with depression, including 67 with NSSI (DN+) and 39 without NSSI (DN-), during social pain, physical pain, and resting-state conditions.
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