ResearchResearch paperData & Datasets · Robotics & Embodied AI · Safety & Alignment1 source · Oct 8, 2026

OA-MAP: Evidence-Grounded Multi-Agent Multimodal Framework for Interpretable Knee Osteoarthritis Progression

To automate the progression assessment workflow and reduce manual effort while providing interpretable findings and supporting evidence, we present OA-MAP, an autonomous multi-agent framework for evidence-grounded assessment of structural and pain progression in KOA.

Key points

  • Knee osteoarthritis (KOA) progression prediction can support patient monitoring, requiring the integration of multimodal data and multidomain expertise.
  • An uncertainty-informed human-in-the-loop mechanism enables clinicians to review and correct intermediate findings, triggering recomputation of affected results.
  • We evaluate the prediction models using 600 participants from the FNIH Osteoarthritis Biomarkers Consortium cohort.
  • A case study illustrates how OA-MAP combines risk estimates with intermediate findings, cross-modal conflicts, literature support, and uncertainty indicators to support interactive review.

Sources (1)

  • [1]OA-MAP: Evidence-Grounded Multi-Agent Multimodal Framework for Interpretable Knee Osteoarthritis Progression
    arXiv (AI, ML, NLP, CV, robotics, multi-agent) · Oct 8, 03:23 PM
    To automate the progression assessment workflow and reduce manual effort while providing interpretable findings and supporting evidence, we present OA-MAP, an autonomous multi-agent framework for evidence-grounded assessment of structural and pain progression in KOA.
    Knee osteoarthritis (KOA) progression prediction can support patient monitoring, requiring the integration of multimodal data and multidomain expertise.

Extractive summary: sentences quoted from the sources.

Related