ResearchResearch paperComputer Vision · Large Language Models · Multimodal Models1 source · Oct 6, 2026

Knee3DVLM: Dual-Sequence Full-Volume Vision-Language Modeling for Comprehensive Knee MRI Assessment

We introduce Knee3DVLM, a sequence-aware VLM that uses full-volume DESS and fluid-sensitive TSE MRI to predict 57 anatomically resolved binary diagnostic targets derived from the MRI Osteoarthritis Knee Score (MOAKS) for structured reporting.

Key points

  • Vision-language models (VLMs) are increasingly being applied to three-dimensional medical imaging, but their application to knee MRI remains limited, particularly for interpreting the complementary sequences used in clinical practice.
  • We evaluated DESS-only, TSE-only, and paired DESS-TSE configurations using subject-disjoint Osteoarthritis Initiative partitions.
  • In a secondary multiclass analysis aligned with the released 3DReasonKnee cohort, Knee3DVLM was numerically higher than the strongest reported 3DReasonKnee configuration across five pathology categories.
  • These findings support dual-sequence full-volume modeling for comprehensive knee MRI assessment.

Sources (1)

  • [1]Knee3DVLM: Dual-Sequence Full-Volume Vision-Language Modeling for Comprehensive Knee MRI Assessment
    arXiv (AI, ML, NLP, CV, robotics, multi-agent) · Oct 6, 02:58 PM
    We introduce Knee3DVLM, a sequence-aware VLM that uses full-volume DESS and fluid-sensitive TSE MRI to predict 57 anatomically resolved binary diagnostic targets derived from the MRI Osteoarthritis Knee Score (MOAKS) for structured reporting.
    Vision-language models (VLMs) are increasingly being applied to three-dimensional medical imaging, but their application to knee MRI remains limited, particularly for interpreting the complementary sequences used in clinical practice.

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