ResearchResearch paperComputer Vision · Multimodal Models · Interpretability1 source · Oct 7, 2026

Geometry-Supervised Visual Representation Learning for Multi-Phenotype Lesion Interpretation in Medical VLMs

To address these limitations, we propose PureVision, a geometry-supervised visual representation learning framework for multi-phenotype lesion interpretation in medical VLMs. It combines a geometry-supervised representation learning module, PureEyes, and an anatomy-guided evidence aggregation module, PureNeurons.

Key points

  • Medical vision-language models (VLMs) have shown increasing potential for clinical image interpretation.
  • Existing vision-language alignment methods produce visual representations that fail to preserve anatomical hierarchies and relationships among phenotypic subclasses.
  • PureNeurons projects visual representations into the learned latent space, using their positions to selectively aggregate lesion-specific anatomical and phenotypic evidence.
  • Experiments on LIDC-IDRI, CBIS-DDSM, and 3DReasonKnee demonstrate that PureVision improves lesion grounding and phenotype characterization in visual question answering and radiology report generation.

Sources (1)

  • [1]Geometry-Supervised Visual Representation Learning for Multi-Phenotype Lesion Interpretation in Medical VLMs
    arXiv (AI, ML, NLP, CV, robotics, multi-agent) · Oct 7, 03:22 PM
    To address these limitations, we propose PureVision, a geometry-supervised visual representation learning framework for multi-phenotype lesion interpretation in medical VLMs. It combines a geometry-supervised representation learning module, PureEyes, and an anatomy-guided evidence aggregation module, PureNeurons.
    Medical vision-language models (VLMs) have shown increasing potential for clinical image interpretation.

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